讲座题目：Practical by Design: Efficient Enantioselective Synthesis of Complex Drug Substances on Large Scale and Research towards a General Method for the Synthesis of P-Stereogenic Chiral Phosphine Ligands
主讲人：Zhengxu (Steve) Han 教授，Boehringer Ingelheim
主持人：姜雪峰 教授
开始时间：2016年5月24日（星期二）下午15:00
讲座地址：中北校区化学馆A205
主办单位：Betway必威西汉姆联
报告人简介：
Zhengxu (Steve) Han was born in China. He received his B.S degree and Ph.D. in physical organic chemistry from Lanzhou University with Professor You-Cheng Liu. In 1991, he moved to Tübingen University, Germany, as a fellow of the Alexander von Humboldt Foundation with Professor Anton Rieker. After postdoctoral research with Professor Stuart Linn at University California, Berkeley, and Professor Lee Magid at the University of Tennessee, Knoxville, he joined the process research group at Sepracorin 1998 and then Boehringer Ingelheim in 2005. He is now a Senior Research Fellow and his research interest center on efficient process and methodology development for asymmetric synthesis.
报告摘要：
The presentation contains two parts. The first part showcases our efforts in developing an enantioselective route for the efficient production of complex drug substance (DS) on large scale. The process features an efficient construction of a sterically hindered multi-heterocyclic API with two chiral centers via Hantzsch reaction, highlyasymmetric hydrogenation of a ketone, lactone formation, and asymmetric reduction of a hemiketal influenced by the substrate’s intrinsic chirality.
The second part focusses on research toward a practical method for asymmetric synthesis of P-stereogenic chiral phosphine oxides as key starting materials for synthesis of P-stereogenic phosphine ligand catalysts.